CD24

Signal transducer CD24, cunoscută și sub denumirea de cluster of differentiation 24 sau heat stable antigen (HSA), este o proteină care la om este codificată de gena CD24. CD24 este o moleculă de adeziune celulară.

CD24
Identificatori
Alias	CD24
Identificări externe	OMIM: 600074 MGI: 88323 GeneCards: CD24
Localizarea genei (om) Cro. Cromozomul uman 6 Bandă 6q21 Start 106,969,831 pb Final 106,975,627 pb
Ontologia genei Funcția moleculară • protein tyrosine kinase activator activity • signal transducer activity • GO:0001948, GO:0016582 legare de proteină • protein kinase binding Componenta celulară • membrană • membrană celulară • suprafață celulară • anchored component of external side of plasma membrane • membrane raft • anchored component of membrane • structură anatomică intracelulară Procesul biologic • răspuns la hipoxie • regulation of MAPK cascade • positive regulation of MAP kinase activity • regulation of cytokine-mediated signaling pathway • positive regulation of cytosolic calcium ion concentration • chemokine receptor transport out of membrane raft • T cell costimulation • regulation of phosphorylation • Wnt signaling pathway • negative regulation of transforming growth factor beta3 production • cell activation • immune response-regulating cell surface receptor signaling pathway • răsouns la estrogen • respiratory burst • intrinsic apoptotic signaling pathway • glomerular parietal epithelial cell differentiation • adeziune celulară • glomerular visceral epithelial cell differentiation • cholesterol homeostasis • regulation of epithelial cell differentiation • response to molecule of bacterial origin • cell migration • B cell receptor transport into membrane raft • positive regulation of nephron tubule epithelial cell differentiation • positive regulation of activated T cell proliferation • positive regulation of protein tyrosine kinase activity • adeziune celulă-celulă Surse: Amigo / QuickGO
Ortologi
Specie	Om	Șoarece
Entrez	100133941	12484
Ensembl	ENSG00000272398	ENSMUSG00000047139
UniProt	P25063	P24807
RefSeq (mRNA)	NM_001291737 NM_001291738 NM_001291739 NM_013230 NM_001359084	NM_009846
RefSeq (proteine)	NP_001278666 NP_001278667 NP_001278668 NP_037362 NP_001346013	NP_033976
Localizare (UCSC)	Chr 6: 106.97 – 106.98 Mb	n/a
Căutare PubMed
Wikidata
Vedeți/Editați Om Vedeți/Editați Șoarece

Funcție

CD24 este o sialoglicoproteină exprimată la suprafața majorității limfocitelor B și neuroblastelor. De asemenea, este exprimată pe neutrofile și precursori ai acestora începând cu stadiul mielocitelor. Proteina codificată este ancorată printr-o legătură glicozil fosfatidilinozitol (GPI) de suprafața celulei. Proteina contribuie, în plus, la o gamă largă de rețele de semnalizare în aval și este crucială pentru dezvoltarea neuronală. Legarea încrucișată a CD24 pe suprafața neutrofilelor induce apoptoza și aceasta pare să fie defectă în sepsis. Gena CD24 este întâlnită pe cromozomul 6 (6q21). O aliniere a secvenței acestei gene găsește locații genomice similare pe cromozomii 1p36, 3p26, 15q21.3, 20q11.2 și Yq11.222.

Bibliografie

• Li D, Zheng L, Jin L, Zhou Y, Li H, Fu J, Shi M, Du P, Wang L, Wu H, Chen GY, Zheng P, Liu Y, Wang FS, Wang S (septembrie 2009). „CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection”. Hepatology. 50 (3): 735–42. doi:10.1002/hep.23047. PMID 19610054. 
• Piotrowski P, Lianeri M, Wudarski M, Łacki JK, Jagodziński PP (iunie 2010). „CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus”. Tissue Antigens. 75 (6): 696–700. doi:10.1111/j.1399-0039.2010.01447.x. PMID 20230526. 
• Honeth G, Bendahl PO, Ringnér M, Saal LH, Gruvberger-Saal SK, Lövgren K, Grabau D, Fernö M, Borg A, Hegardt C (2008). „The CD44+/CD24- phenotype is enriched in basal-like breast tumors”. Breast Cancer Research. 10 (3): R53. doi:10.1186/bcr2108. PMC 2481503 . PMID 18559090. 
• Nagy B, Szendroi A, Romics I (iunie 2009). „Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy”. Pathology Oncology Research. 15 (2): 279–83. doi:10.1007/s12253-008-9077-1. PMID 18752058. 
• Kim KH, Choi JS, Kim JM, Choi YL, Shin YK, Lee HC, Seong IO, Kim BK, Chae SW, Kim SH (martie 2009). „Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium”. Histology and Histopathology. 24 (3): 309–16. doi:10.14670/HH-24.309. PMID 19130400. 
• Buess M, Rajski M, Vogel-Durrer BM, Herrmann R, Rochlitz C (octombrie 2009). „Tumor-endothelial interaction links the CD44(+)/CD24(-) phenotype with poor prognosis in early-stage breast cancer”. Neoplasia. 11 (10): 987–1002. doi:10.1593/neo.09670. PMC 2745665 . PMID 19794958. 
• Pruszak J, Ludwig W, Blak A, Alavian K, Isacson O (decembrie 2009). „CD15, CD24, and CD29 define a surface biomarker code for neural lineage differentiation of stem cells”. Stem Cells. 27 (12): 2928–40. doi:10.1002/stem.211. PMC 3322476 . PMID 19725119. 
• Liu Y, Chen GY, Zheng P (decembrie 2009). „CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns”. Trends in Immunology. 30 (12): 557–61. doi:10.1016/j.it.2009.09.006. PMC 2788100 . PMID 19786366. 
• Vesuna F, Lisok A, Kimble B, Raman V (decembrie 2009). „Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression”. Neoplasia. 11 (12): 1318–28. doi:10.1593/neo.91084. PMC 2794513 . PMID 20019840. 
• Sagiv E, Arber N (februarie 2008). „The novel oncogene CD24 and its arising role in the carcinogenesis of the GI tract: from research to therapy”. Expert Review of Gastroenterology & Hepatology^⁠(d). 2 (1): 125–33. doi:10.1586/17474124.2.1.125. PMID 19072375. 
• Bauerschmitz GJ, Ranki T, Kangasniemi L, Ribacka C, Eriksson M, Porten M, Herrmann I, Ristimäki A, Virkkunen P, Tarkkanen M, Hakkarainen T, Kanerva A, Rein D, Pesonen S, Hemminki A (iulie 2008). „Tissue-specific promoters active in CD44+CD24-/low breast cancer cells”. Cancer Research. 68 (14): 5533–9. doi:10.1158/0008-5472.CAN-07-5288. PMID 18632604. 
• Carl JW, Liu JQ, Joshi PS, El-Omrani HY, Yin L, Zheng X, Whitacre CC, Liu Y, Bai XF (iulie 2008). „Autoreactive T cells escape clonal deletion in the thymus by a CD24-dependent pathway”. Journal of Immunology. 181 (1): 320–8. doi:10.4049/jimmunol.181.1.320. PMID 18566397. 
• Baumhoer D, Riener MO, Zlobec I, Tornillo L, Vogetseder A, Kristiansen G, Dietmaier W, Hartmann A, Wuensch PH, Sessa F, Ruemmele P, Terracciano LM (februarie 2009). „Expression of CD24, P-cadherin and S100A4 in tumors of the ampulla of Vater”. Modern Pathology. 22 (2): 306–13. doi:10.1038/modpathol.2008.192. PMID 19043399. 
• Wang W, Wang X, Peng L, Deng Q, Liang Y, Qing H, Jiang B (ianuarie 2010). „CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation”. Cancer Science. 101 (1): 112–9. doi:10.1111/j.1349-7006.2009.01370.x. PMID 19860845. 
• Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, Saito K, Sohda M, Nakajima M, Nakajima T, Kuwano H (februarie 2009). „CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma”. Annals of Surgical Oncology. 16 (2): 506–14. doi:10.1245/s10434-008-0252-0. PMID 19050962. 
• Yang XR, Xu Y, Yu B, Zhou J, Li JC, Qiu SJ, Shi YH, Wang XY, Dai Z, Shi GM, Wu B, Wu LM, Yang GH, Zhang BH, Qin WX, Fan J (septembrie 2009). „CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery”. Clinical Cancer Research. 15 (17): 5518–27. doi:10.1158/1078-0432.CCR-09-0151. PMID 19706825. 
• Lee JH, Kim SH, Lee ES, Kim YS (noiembrie 2009). „CD24 overexpression in cancer development and progression: a meta-analysis”. Oncology Reports. 22 (5): 1149–56. doi:10.3892/or_00000548. PMID 19787233. 
• Gekara NO, Weiss S (noiembrie 2004). „Lipid rafts clustering and signalling by listeriolysin O”. Biochemical Society Transactions. 32 (Pt 5): 712–4. doi:10.1042/BST0320712. PMID 15493995. 
• Athanassiadou P, Grapsa D, Gonidi M, Athanassiadou AM, Tsipis A, Patsouris E (2009). „CD24 expression has a prognostic impact in breast carcinoma”. Pathology, Research and Practice. 205 (8): 524–33. doi:10.1016/j.prp.2009.01.008. PMID 19243896. 
• Ronaghi M, Vallian S, Etemadifar M (decembrie 2009). „CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population”. Psychiatry Research. 170 (2–3): 271–2. doi:10.1016/j.psychres.2009.01.002. PMID 19896210. 
• van de Peppel J, Schaaf G, Matos A, Guo Y, Strini T, Verschoor W, Dudakovic A, van Wijnen A, van Leeuwen J (martie 2021). „Cell Surface Glycoprotein CD24 Marks Bone Marrow-Derived Human Mesenchymal Stem/Stromal Cells with Reduced Proliferative and Differentiation Capacity In Vitro”. Stem Cells & Development: 325–336. doi:10.1089/scd.2021.0027. PMID 33593128.