Hepatoprotecție

Hepatoprotecția reprezintă capacitatea unui compus de a produce preveni afectarea de la nivel hepatic, care poate fi indusă de substanțe heptatotoxice (precum: tetraclorură de carbon, tioacetamidă).^[1] În unele cazuri se pot utiliza și antidoturi specifice: supradozarea de paracetamol duce la un risc mare de dezvoltare al insuficienței hepatice acute, caz în care se poate administra acetilcisteină.^[2]

Au fost descrise numeroase specii vegetale care prezintă în compoziția lor compuși cu potențial hepatoprotector:

Astragalus membranaceus^[3]
Curcuma longa^[4]
Brassica^[5]
Silybum marianum (lignani de tipul silibinină din silimarină)^[6]
Andrographis paniculata^[7]
Alchemilla vulgaris^[8]

Note

^ Kumar A, Nishant R, Kumar N, Gautam P (2013). „Mechanisms involved in hepatoprotection of different herbal products: A Review”. International Journal of Research in Pharmaceutical Sciences (în engleză). 4: 112–117.
^ Waring WS. „Novel acetylcysteine regimens for treatment of paracetamol overdose”. Ther Adv Drug Saf (în engleză). 3 (6): 305–315. doi:10.1177/2042098612464265. PMC 4110842  . PMID 25083244.
^ Chien, CF; Wu, YT; Tsai, TH (2011). „Biological analysis of herbal medicines used for the treatment of liver diseases”. Biomedical Chromatography. 25 (1–2): 21–38. doi:10.1002/bmc.1568. PMID 21204110.
^ Ghosh, N; Ghosh, R; Mandal, V; Mandal, SC (2011). „Recent advances in herbal medicine for treatment of liver diseases”. Pharmaceutical Biology. 49 (9): 970–88. doi:10.3109/13880209.2011.558515. PMID 21595500.
^ Steinkellner, H; Rabot, S; Freywald, C; Nobis, E; Scharf, G; Chabicovsky, M; Knasmüller, S; Kassie, F (1 d.Hr.). „Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens”. Mutation Research. 480-481: 285–97. doi:10.1016/S0027-5107(01)00188-9. PMID 11506821.
^ Saller R, Brignoli R, Melzer J, Meier R (2008). „An updated systematic review with meta-analysis for the clinical evidence of silymarin”. Forschende Komplementärmedizin. 15 (1): 9–20. doi:10.1159/000113648. PMID 18334810. Accesat în 14 decembrie 2010.
^ Andrographis paniculata http://www.stuartxchange.com/Sinta.html
^ El-Hadidy, Eshak Mourad; Refat, Omnia G.; Halaby, Mona; Elmetwaly, Eman M.; Omar, Aya A.A (2018). „Effect of Lion's Foot (Alchemilla vulgaris) on Liver and Renal Functions in Rats Induced by CCI”. Food and Nutrition Sciences: 46–62.

Vezi și

Hepatotoxicitate

[1] Kumar A, Nishant R, Kumar N, Gautam P (2013). „Mechanisms involved in hepatoprotection of different herbal products: A Review”. International Journal of Research in Pharmaceutical Sciences (în engleză). 4: 112–117.

[2] Waring WS. „Novel acetylcysteine regimens for treatment of paracetamol overdose”. Ther Adv Drug Saf (în engleză). 3 (6): 305–315. doi:10.1177/2042098612464265. PMC 4110842  . PMID 25083244.

[3] Chien, CF; Wu, YT; Tsai, TH (2011). „Biological analysis of herbal medicines used for the treatment of liver diseases”. Biomedical Chromatography. 25 (1–2): 21–38. doi:10.1002/bmc.1568. PMID 21204110.

[4] Ghosh, N; Ghosh, R; Mandal, V; Mandal, SC (2011). „Recent advances in herbal medicine for treatment of liver diseases”. Pharmaceutical Biology. 49 (9): 970–88. doi:10.3109/13880209.2011.558515. PMID 21595500.

[5] Steinkellner, H; Rabot, S; Freywald, C; Nobis, E; Scharf, G; Chabicovsky, M; Knasmüller, S; Kassie, F (1 d.Hr.). „Effects of cruciferous vegetables and their constituents on drug metabolizing enzymes involved in the bioactivation of DNA-reactive dietary carcinogens”. Mutation Research. 480-481: 285–97. doi:10.1016/S0027-5107(01)00188-9. PMID 11506821.

[Saller2008-6] Saller R, Brignoli R, Melzer J, Meier R (2008). „An updated systematic review with meta-analysis for the clinical evidence of silymarin”. Forschende Komplementärmedizin. 15 (1): 9–20. doi:10.1159/000113648. PMID 18334810. Accesat în 14 decembrie 2010.

[7] Andrographis paniculata http://www.stuartxchange.com/Sinta.html

[8] El-Hadidy, Eshak Mourad; Refat, Omnia G.; Halaby, Mona; Elmetwaly, Eman M.; Omar, Aya A.A (2018). „Effect of Lion's Foot (Alchemilla vulgaris) on Liver and Renal Functions in Rats Induced by CCI”. Food and Nutrition Sciences: 46–62.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]